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We use contemporary molecular, cellular and biochemical techniques as well as modern genome-wide methodologies to study role of Aryl hydrocarbon Receptor (AhR), its ligands, cofactors, and target genes in liver and metabolic diseases. Our goal is to develop translational approach to Aryl hydrocarbon Receptor biology by identifying and characterizing therapeutically useful Aryl hydrocarbon Receptor agonists to protect against alcoholic and metabolic dysfunction-associated steatotic liver disease.