Publications

Complete list of publications at PubMed

Chakrabarty B, Thakur NS, Joshi AD, Agrahari V. Rationally designed sodium thiosulfate-loaded solid lipid nanoparticles for inner ear delivery and prevention of medication-induced ototoxicity. J Mater Chem B. 2025 Oct 27;. doi: 10.1039/d5tb01324k. [Epub ahead of print] PubMed PMID: 41140199; PubMed Central PMCID: PMC12557298.

Patil NY, Rus I, Ampadu F, Abu Shukair HM, Bonvicino S, Brush RS, Eaton E, Agbaga MP, Oh TG, Friedman JE, Joshi AD. Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating aryl hydrocarbon receptor-dependent AMPK signaling. Am J Physiol Gastrointest Liver Physiol. 2025 Apr 1;328(4):G433-G447. doi: 10.1152/ajpgi.00337.2024. Epub 2025 Mar 10. PubMed PMID: 40062565; PubMed Central PMCID: PMC12258133.

Orlowska K, Nault R, Ara J, LaPres JJ, Harkema J, Demireva EY, Xie H, Wilson RH, Bradfield CA, Yap D, Joshi A, Elferink CJ, Zacharewski T. Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity. Redox Biol. 2024 Nov;77:103405. doi: 10.1016/j.redox.2024.103405. Epub 2024 Oct 22. PubMed PMID: 39490313; PubMed Central PMCID: PMC11543540.

Thakur NS, Rus I, Herbert A, Zallocchi M, Chakrabarty B, Joshi AD, Lomeo J, Agrahari V. Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear. J Nanobiotechnology. 2024 Aug 13;22(1):482. doi: 10.1186/s12951-024-02686-z. PubMed PMID: 39135039; PubMed Central PMCID: PMC11321169.

Ampadu F, Awasthi V, Joshi AD. Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases. J Pharmacol Exp Ther. 2024 Jul 18;390(2):233-239. doi: 10.1124/jpet.124.002065. Review. PubMed PMID: 38844365; PubMed Central PMCID: PMC11264251.

Eeda V, Patil NY, Joshi AD, Awasthi V. Advancements in metabolic-associated steatotic liver disease research: Diagnostics, small molecule developments, and future directions. Hepatol Res. 2024 Mar;54(3):222-234. doi: 10.1111/hepr.14008. Epub 2024 Jan 22. Review. PubMed PMID: 38149861; PubMed Central PMCID: PMC10923026.

Patil NY, Rus I, Joshi AD. Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2-Mediated Protection against Alcohol-Induced Apoptosis. J Pharmacol Exp Ther. 2023 Oct;387(1):111-120. doi: 10.1124/jpet.123.001670. Epub 2023 Aug 10. PubMed PMID: 37562971; PubMed Central PMCID: PMC10519581.

Patil NY, Friedman JE, Joshi AD. Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease. Receptors (Basel). 2023 Mar;2(1):1-15. doi: 10.3390/receptors2010001. Epub 2023 Jan 4. PubMed PMID: 37284280; PubMed Central PMCID: PMC10240927.

Patil NY, Rus I, Downing E, Mandala A, Friedman JE, Joshi AD. Cinnabarinic Acid Provides Hepatoprotection Against Nonalcoholic Fatty Liver Disease. J Pharmacol Exp Ther. 2022 Oct;383(1):32-43. doi: 10.1124/jpet.122.001301. Epub 2022 Aug 6. PubMed PMID: 35933113; PubMed Central PMCID: PMC9513857.

Joshi AD, Thinakaran G, Elferink C. Cinnabarinic Acid-Induced Stanniocalcin 2 Confers Cytoprotection against Alcohol-Induced Liver Injury. J Pharmacol Exp Ther. 2022 Apr;381(1):1-11. doi: 10.1124/jpet.121.000999. Epub 2022 Jan 25. PubMed PMID: 35078862; PubMed Central PMCID: PMC8998678.

Patil NY, Tang H, Rus I, Zhang K, Joshi AD. Decoding Cinnabarinic Acid-Specific Stanniocalcin 2 Induction by Aryl Hydrocarbon Receptor. Mol Pharmacol. 2022 Jan;101(1):45-55. doi: 10.1124/molpharm.121.000376. Epub 2021 Nov 11. PubMed PMID: 34764210; PubMed Central PMCID: PMC8969126.

Girer NG, Rontoyanni VG, Joshi A, Patrikeev I, Murton AJ, Porter C, Motamedi M, Elferink CJ. Liver-Specific Nonviral Gene Delivery of Fibroblast Growth Factor 21 Protein Expression in Mice Regulates Body Mass and White/Brown Fat Respiration. J Pharmacol Exp Ther. 2021 Aug;378(2):157-165. doi: 10.1124/jpet.121.000514. Epub 2021 Jun 1. PubMed PMID: 34074713; PubMed Central PMCID: PMC8686718.

Joshi AD. New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2. Front Endocrinol (Lausanne). 2020;11:172. doi: 10.3389/fendo.2020.00172. eCollection 2020. Review. PubMed PMID: 32296395; PubMed Central PMCID: PMC7136389.

Joshi AD, Hossain E, Elferink CJ. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Mol Pharmacol. 2017 Sep;92(3):366-374. doi: 10.1124/mol.117.108878. Epub 2017 Jul 10. PubMed PMID: 28696214; PubMed Central PMCID: PMC5553190.

Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659. PubMed PMID: 28337975; PubMed Central PMCID: PMC5376670.

Wright EJ, De Castro KP, Joshi AD, Elferink CJ. Canonical and non-canonical aryl hydrocarbon receptor signaling pathways. Curr Opin Toxicol. 2017 Feb;2:87-92. doi: 10.1016/j.cotox.2017.01.001. Epub 2017 Jan 18. PubMed PMID: 32296737; PubMed Central PMCID: PMC7158745.

Gaziova I, Jackson D, Boor PJ, Carter D, Cruz-Monserrate Z, Elferink CJ, Joshi AD, Kaphalia B, Logsdon CD, Pereira de Castro K, Soong L, Tao X, Qiu S, Elferink LA. The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury. PLoS One. 2016;11(10):e0165485. doi: 10.1371/journal.pone.0165485. eCollection 2016. PubMed PMID: 27798657; PubMed Central PMCID: PMC5087859.

Joshi AD, Mustafa MG, Lichti CF, Elferink CJ. Homocitrullination Is a Novel Histone H1 Epigenetic Mark Dependent on Aryl Hydrocarbon Receptor Recruitment of Carbamoyl Phosphate Synthase 1. J Biol Chem. 2015 Nov 13;290(46):27767-78. doi: 10.1074/jbc.M115.678144. Epub 2015 Sep 30. PubMed PMID: 26424795; PubMed Central PMCID: PMC4646023.

Jackson DP, Joshi AD, Elferink CJ. Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs. Toxicol Res (Camb). 2015 Sep 1;4(5):1143-1158. doi: 10.1039/c4tx00236a. Epub 2015 Mar 17. PubMed PMID: 26783425; PubMed Central PMCID: PMC4714567.

Joshi AD, Carter DE, Harper TA Jr, Elferink CJ. Aryl hydrocarbon receptor-dependent stanniocalcin 2 induction by cinnabarinic acid provides cytoprotection against endoplasmic reticulum and oxidative stress. J Pharmacol Exp Ther. 2015 Apr;353(1):201-12. doi: 10.1124/jpet.114.222265. Epub 2015 Feb 11. PubMed PMID: 25672339; PubMed Central PMCID: PMC11047083.

Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem. 2014 Sep 12;289(37):25556-70. doi: 10.1074/jbc.M114.586289. Epub 2014 Jul 22. PubMed PMID: 25053409; PubMed Central PMCID: PMC4162161.

Jackson DP, Li H, Mitchell KA, Joshi AD, Elferink CJ. Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression. Mol Pharmacol. 2014 Apr;85(4):533-41. doi: 10.1124/mol.113.089730. Epub 2014 Jan 15. PubMed PMID: 24431146; PubMed Central PMCID: PMC3965890.

Wilson SR, Joshi AD, Elferink CJ. The tumor suppressor Kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner. J Pharmacol Exp Ther. 2013 Jun;345(3):419-29. doi: 10.1124/jpet.113.203786. Epub 2013 Mar 19. PubMed PMID: 23512538; PubMed Central PMCID: PMC3657114.

Harper TA Jr, Joshi AD, Elferink CJ. Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene. J Pharmacol Exp Ther. 2013 Mar;344(3):579-88. doi: 10.1124/jpet.112.201111. Epub 2012 Dec 26. PubMed PMID: 23269473; PubMed Central PMCID: PMC3583502.

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Jan 8;18(2):244-51. doi: 10.1038/nm.2598. PubMed PMID: 22231556; PubMed Central PMCID: PMC3274651.

Pajor AM, Sun NN, Joshi AD, Randolph KM. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun;1808(6):1454-61. doi: 10.1016/j.bbamem.2010.11.007. Epub 2010 Nov 10. PubMed PMID: 21073858; PubMed Central PMCID: PMC3046213.

Lanner JT, Georgiou DK, Joshi AD, Hamilton SL. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996. doi: 10.1101/cshperspect.a003996. Epub 2010 Oct 20. Review. PubMed PMID: 20961976; PubMed Central PMCID: PMC2964179.

Joshi AD, Pajor AM. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 7;48(13):3017-24. doi: 10.1021/bi8022625. PubMed PMID: 19260674; PubMed Central PMCID: PMC2666955.

Joshi AD, Pajor AM. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 4;45(13):4231-9. doi: 10.1021/bi052064y. PubMed PMID: 16566597; PubMed Central PMCID: PMC2547120.